AffiAB® 488 Conjugated Anti-Cytokeratin 9 Antibody [SD201-09]

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CAT# AFG-HB-4244
Size: 100 μL

386.10 386.1 USD 386.10

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AffiAB® 488 Conjugated Anti-Cytokeratin 9 Antibody [SD201-09]

Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratin 9 is an unusually large, type I acidic cytokeratin that differentiates human plantar and palmar epidermal cells. Cytokeratin 9 localizes to the suprabasal layers as well as the upper epidermal layers such as the glandular ridges and interridges. The domains of cytokeratin 9 include a head, an α-helical coiled-coil-forming rod, and a tail; cytokeratin 9 shares significant homology with cytokeratin 10. Mutations in the cytokeratin 9 gene correlate with the development of epidermolytic palmoplantar keratoderma (EPPK) , an autosomal dominant inherited skin disorder that is characterized by hyperkeratosis of the skin over the palms and soles.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P35527 Human; SwissProt: Q6RHW0 Mouse

Recombinant

YES

Conjugation

iFluor™ 488

Host

Rabbit

Isotype

IgG

Clone

SD201-09

KO/KD

N/A

Species reactivity

Human, Mouse

Tested applications

IF-Tissue

Predicted species reactivity

N/A

Immunogen

Recombinant protein wiehin Human Cytokeratin 9 aa 234-422 / 623.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:200

Molecular Weight

Predicted band size: 62 kDa

Subcellular location

Extracellular exosome, membrane, nucleus.

Positive control

Rat skin tissue.