AffiAB® 488 Conjugated Anti-Cytokeratin 7 Antibody [ST50-05]

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CAT# AFG-HB-4242
Size: 100 μL

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    AffiAB® 488 Conjugated Anti-Cytokeratin 7 Antibody [ST50-05]

    Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. Cytokeratin 7 (also known as sarcolectin) agglutinates normal and transformed cells with a high affinity for simple sugars. Cytokeratin 7 also inhibits the synthesis of interferon-dependent secondary proteins thus reversing the antiviral effect of interferon induction and restoring cells to their status ad primum. In normal and transformed cells, Cytokeratin 7 localizes to the membrane.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P08729 Human

    Recombinant

    YES

    Conjugation

    iFluor™ 488

    Host

    Rabbit

    Isotype

    IgG

    Clone

    ST50-05

    KO/KD

    N/A

    Species reactivity

    Human, Mouse

    Tested applications

    IF-Tissue, IF-Cell, FC

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human Cytokeratin 7 aa 18-67.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:200; IF-Cell: 1:100; FC: 1:500-1:1, 000

    Molecular Weight

    Predicted band size: 51 kDa

    Subcellular location

    Cytoplasm.

    Positive control

    Human liver tissue, A431, human breast tissue, SK-Br-3.

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