AffiAB® 488 Conjugated Anti-Cytokeratin 6 Antibody [SN71-07]

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CAT# AFG-HB-4241
Size: 100 μL

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AffiAB® 488 Conjugated Anti-Cytokeratin 6 Antibody [SN71-07]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F) , encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P02538 Human; SwissProt: P04259 Human; SwissProt: P48668 Human

Recombinant

YES

Conjugation

iFluor™ 488

Host

Rabbit

Isotype

IgG

Clone

SN71-07

KO/KD

N/A

Species reactivity

Human, Rat

Tested applications

IF-Cell

Predicted species reactivity

N/A

Immunogen

Recombinant protein within Human Cytokeratin 6 aa 1-118 / 564.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100

Molecular Weight

Predicted band size: 60 kDa

Subcellular location

Keratin filament, cytosol, extracellular exosome, nucleus, membrane.

Positive control

A431.