AffiAB® 488 Conjugated Anti-Cytokeratin 19 Antibody [SA30-06]

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CAT# AFG-HB-4238
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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    AffiAB® 488 Conjugated Anti-Cytokeratin 19 Antibody [SA30-06]

    Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells and have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. For example, many types of cancer cells express Cytokeratin 19 (CK19) , an epithelial cytoskeletal protein within the suprabasal squamous epithelium. Cytokeratin 19 is a specific marker of moderate to severe dysplasia and carcinoma in situ in oral cavity squamous epithelium, and measurement of Cytokeratin 19 may be a useful marker in diagnosing hepatoma. Cytokeratin 19 fragment levels in serum have been documented as a marker for lung cancer. Clinical investigations have suggested that serum CYFRA 21-1, a fragment of Cytokeratin 19, may be among the most useful tumor markers.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P08727 Human; SwissProt: P19001 Mouse

    Recombinant

    YES

    Conjugation

    iFluor™ 488

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SA30-06

    KO/KD

    N/A

    Species reactivity

    Human, Mouse

    Tested applications

    IF-Cell

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human Cytokeratin 19 aa 348-400.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Cell: 1:100

    Molecular Weight

    Predicted band size: 44 kDa

    Subcellular location

    Cytoskeleton.

    Positive control

    MCF-7.

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