AffiAB® 488 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

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CAT# AFG-HB-4237
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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AffiAB® 488 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. For example, Cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while Cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas. Cytokeratin 18 contains two major phosphorylation sites on Ser 33 and Ser 52. Phosphorylation of Ser 18 is essential for the association of Cytokeratin 18 with 14-3-3 proteins and is involved in keratin organization and distribution.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P05783 Human; SwissProt: P05784 Mouse; SwissProt: Q5BJY9 Rat

Recombinant

YES

Conjugation

iFluor™ 488

Host

Rabbit

Isotype

IgG

Clone

SZ80-07

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Tissue, IF-Cell

Predicted species reactivity

N/A

Immunogen

Recombinant protein within mouse Cytokeratin 18 aa 200-423.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:50; IF-Cell: 1:100

Molecular Weight

Predicted band size: 48 kDa

Subcellular location

Cytoplasm, Nucleus.

Positive control

Human kidney tissue, SK-Br-3.