AffiAB® 488 Conjugated Anti-Cytokeratin 17 Antibody [SR45-06]

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CAT# AFG-HB-4236
Size: 100 μL

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    AffiAB® 488 Conjugated Anti-Cytokeratin 17 Antibody [SR45-06]

    Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs) . It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: Q04695 Human; SwissProt: Q9QWL7 Mouse

    Recombinant

    YES

    Conjugation

    iFluor™ 488

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SR45-06

    KO/KD

    N/A

    Species reactivity

    Human, Mouse

    Tested applications

    IF-Tissue, IF-Cell

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human Cytokeratin 17 aa 1-50 / 432.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:200; IF-Cell: 1:100

    Molecular Weight

    Predicted band size: 48 kDa

    Subcellular location

    Cytoplasm.

    Positive control

    Human esophagus tissue, Hela.

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