AffiAB® 488 Conjugated Anti-Cytokeratin 17 Antibody [SR45-06]

https://www.affiab.com/web/image/product.template/116613/image_1920?unique=d674372

CAT# AFG-HB-4236
Size: 100 μL

386.10 386.1 USD 386.10

386.10

For Price Contact info@affigen.com

This combination does not exist.

Terms and Conditions
30-day money-back guarantee
Shipping: 2-3 Business Days

AffiAB® 488 Conjugated Anti-Cytokeratin 17 Antibody [SR45-06]

Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs) . It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: Q04695 Human; SwissProt: Q9QWL7 Mouse

Recombinant

YES

Conjugation

iFluor™ 488

Host

Rabbit

Isotype

IgG

Clone

SR45-06

KO/KD

N/A

Species reactivity

Human, Mouse

Tested applications

IF-Tissue, IF-Cell

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human Cytokeratin 17 aa 1-50 / 432.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:200; IF-Cell: 1:100

Molecular Weight

Predicted band size: 48 kDa

Subcellular location

Cytoplasm.

Positive control

Human esophagus tissue, Hela.