AffiAB® 488 Conjugated Anti-Cytokeratin 16 Antibody [SC52-09]

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CAT# AFG-HB-4235
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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    AffiAB® 488 Conjugated Anti-Cytokeratin 16 Antibody [SC52-09]

    Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1) , nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN) .

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P08779 Human

    Recombinant

    YES

    Conjugation

    iFluor™ 488

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SC52-09

    KO/KD

    N/A

    Species reactivity

    Human

    Tested applications

    IF-Tissue, IF-Cell

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within human Cytokeratin 16 aa 27-75.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:50-1:200; IF-Cell: 1:100

    Molecular Weight

    Predicted band size: 51 kDa

    Subcellular location

    Cytoskeleton, Nucleus.

    Positive control

    Human esophagus tissue, human skin tissue, HepG2.

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