AffiAB® 488 Conjugated Anti-Cytokeratin 14 Antibody [SC65-06]

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CAT# AFG-HB-4233
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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    AffiAB® 488 Conjugated Anti-Cytokeratin 14 Antibody [SC65-06]

    Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P02533 Human; SwissProt: Q61781 Mouse; SwissProt: Q6IFV1 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 488

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SC65-06

    KO/KD

    N/A

    Species reactivity

    Mouse, Rat, Human

    Tested applications

    IF-Tissue, IF-Cell

    Predicted species reactivity

    N/A

    Immunogen

    Recombinant protein within Human Cytokeratin 14 aa 250-484.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:100; IF-Cell: 1:100

    Molecular Weight

    Predicted band size: 52 kDa

    Subcellular location

    Cytoplasm, Nucleus.

    Positive control

    Rat skin tissue, B16F1.

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