AffiAB® 488 Conjugated Anti-Collagen VI Antibody [SD83-03]

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CAT# AFG-HB-4230
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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AffiAB® 488 Conjugated Anti-Collagen VI Antibody [SD83-03]

This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P12109 Human; SwissProt: P12110 Human; SwissProt: P12111 Human; SwissProt: Q02788 Mouse; SwissProt: Q04857 Mouse

Recombinant

YES

Conjugation

iFluor™ 488

Host

Rabbit

Isotype

IgG

Clone

SD83-03

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Cell, IF-Tissue

Predicted species reactivity

N/A

Immunogen

Recombinant protein within Human Collagen VI aa 17-255 / 1, 028.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100; IF-Tissue: 1:50

Molecular Weight

Predicted band size: 109 kDa

Subcellular location

Extracellular matrix.

Positive control

Hela, mouse colon tissue.