AffiAB® 488 Conjugated Anti-CD47 Antibody [1B1]

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CAT# AFG-HB-4229
Size: 100 μL

354.60 354.6 USD 354.60

354.60

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AffiAB® 488 Conjugated Anti-CD47 Antibody [1B1]

CD47 is an integral membrane protein that plays a role in the regulation of cation fluxes across cell membranes. Specifically, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to the extracellular matrix. It is also a receptor for the C-terminal cell binding domain of thrombospondin (SIRP) . Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. CD47 is absent from Rh-null erythrocytes, but does play a role in cell adhesion in non-erythroid cells and may prevent premature elimination of erythrocytes. It may also be involved in membrane permeability changes following viral infection. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity) . Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. CD47 is expressed on hemopoietic cells, epithelial cells, endothelial cells and fibroblasts and is strongly expressed in brain and mesenchymal cells.

Antibody type

Mouse monoclonal Antibody

Uniprot ID

SwissProt: Q08722 Human

Recombinant

NO

Conjugation

iFluor™ 488

Host

Mouse

Isotype

IgG1

Clone

1B1

KO/KD

N/A

Species reactivity

Human

Tested applications

FC

Predicted species reactivity

N/A

Immunogen

Recombinant protein within human CD47 aa 19-141 (Extracellular) .

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

2 mg/mL.

Purity

Immunogen affinity purified.

Signal pathway

N/A

Recommended dilutions

FC: 1:500

Molecular Weight

35 kDa

Subcellular location

Cell membrane.

Positive control

MCF-7.