AffiAB® Anti-ZIP12 Antibody
Acts as a zinc-influx transporter (Potential) . May be partly involved in the outbreak of schizophrenia. On the basis of sequence homology, the human SLC39A12 gene has been included as a member of a family of zinc (Zn) transporters designated as the ZRT-IRT-like proteins (current designation SLC39) . ZRT-IRT-like proteins act in concert with another family of transporters, known in non-mammalian organisms as cation diffusion facilitators and in mammals as zinc transporters (ZnT) , to regulate the distribution of Zn in the extra- versus intracellular milieu and within cellular compartments. Hence the ZnT maintain Zn homeostasis that is critical for the normal functioning of tissues including the CNS.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q504Y0 Human; SwissProt: Q5FWH7 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human ZIP12 aa 685-691 / 691 (Extracellular) .
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000; IF-Cell: 1:50-1:200; IHC-P: 1:50-1:200
Molecular Weight
70 kDa
Subcellular location
Membrane.
Positive control
HepG2, N2A, SH-SY5Y, rat lung tissue, mouse liver tissue, mouse brain tissue, mouse eyeball tissue.