![AffiAB® Anti-Zic1 Antibody [JA31-60]](/web/image/product.product/89388/image_1024/%5BAFG-HB-4179%5D%20AffiAB%C2%AE%20Anti-Zic1%20Antibody%20%5BJA31-60%5D%20?unique=a48b62f)
AffiAB® Anti-Zic1 Antibody [JA31-60]
ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family. ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins is critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy-Walker malformation.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q15915 Human; SwissProt: P46684 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA31-60
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human Zic1 aa 1-50 / 447.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000
; IHC-P: 1:50-1:200
; FC: 1:50-1:100
Molecular Weight
Predicted band size: 48 kDa
Subcellular location
Nucleus. Cytoplasm.
Positive control
Rat brain tissue, mouse brain tissue, SH-SY5Y.