AffiAB® Anti-YARS2 Antibody
Catalyzes the attachment of tyrosine to tRNA (Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA (Tyr) . Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:613561] . MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: F1Q4R5 Zebrafish
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Zebrafish
Tested applications
IF-Tissue, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within zebrafish YARS2 aa 251-474 / 474.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
IF-Tissue:1:50-1:200; IHC-P:1:50-1:200
Molecular Weight
53 kDa
Subcellular location
Cytosol. Mitochondrion.
Positive control
Zebrafish.