AffiAB® Anti-XRCC1 Antibody [JA11-47]

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CAT# AFG-HB-4155
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-XRCC1 Antibody [JA11-47]

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V (D) J recombination. Any defect in one of the known components of the DNA repair/V (D) J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V (D) J rearrangement process and early block in both T and B cell maturation.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P18887 Human; SwissProt: Q60596 Mouse; SwissProt: Q9ESZ0 Rat

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

JA11-47

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

WB, IHC-P

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human XRCC1 aa 17-53 / 633.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:500-1:2, 000 ; IHC-P: 1:50-1:200

Molecular Weight

Predicted band size: 70 kDa

Subcellular location

Nucleus.

Positive control

Hela cell lysate, mouse testis tissue, human breast infiltrating duct carcinoma tissue, human colon carcinoma tissue.