AffiAB® Anti-XBP1 Antibody
X-box-binding protein 1 is a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR) . It acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE) . XBP1 binds DNA preferably to the CRE-like element 5'-GATGACGTG [TG] N3 [AT] T-3', and also to some TPA response elements (TRE) . A major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode) .
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P17861 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human
Tested applications
WB
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within C-terminal human XBP1.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Parkinson’s disease, Amyotrophic lateral sclerosis, Alzheimer disease
Recommended dilutions
WB: 1:500-1:1, 000
Molecular Weight
Predicted band size: 29 kDa
Subcellular location
Nucleus
Positive control
HepG2 cell lysates.