![AffiAB® Anti-WDR5 Antibody [JM73-53]](/web/image/product.product/89334/image_1024/%5BAFG-HB-4124%5D%20AffiAB%C2%AE%20Anti-WDR5%20Antibody%20%5BJM73-53%5D%20?unique=a48b62f)
AffiAB® Anti-WDR5 Antibody [JM73-53]
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P61964 Human; SwissProt: P61965 Mouse; SwissProt: Q498M4 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM73-53
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human WDR5 aa 285-334 / 334.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000
; IHC-P: 1:50-1:200
; FC: 1:50-1:100
Molecular Weight
Predicted band size: 37 kDa
Subcellular location
Nucleus.
Positive control
Hela cell lysate, A549 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse brain tissue, human breast carcinoma tissue, human colon carcinoma tissue, human thyroid tissue, Hela.