![AffiAB® Anti-WDR41 Antibody [A9C10]](/web/image/product.product/89332/image_1024/%5BAFG-HB-4122%5D%20AffiAB%C2%AE%20Anti-WDR41%20Antibody%20%5BA9C10%5D%20?unique=b83e256)
AffiAB® Anti-WDR41 Antibody [A9C10]
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy 1, 2, 3, 4. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation 5. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: Q9HAD4 Human; Entrez Gene: 361879 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgG1
Clone
A9C10
KO/KD
N/A
Species reactivity
Human, Rat
Tested applications
WB, IHC-P, IF-Cell
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human aa 231-430 / 459.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
PBS (pH7.4) , 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:1, 000; IHC-P: 1:1, 000; IF-Cell: 1:200
Molecular Weight
Predicted band size: 52 kDa
Subcellular location
Cytoplasm.
Positive control
Daudi cell lysate, SiHa cell lysate, rat kidney tissue, human testis tissue, human colon tissue, Hela.