AffiAB® Anti-Vitamin D Binding protein Antibody [JM10-36]

Vitamin D-binding protein (DBP) , also/originally known as gc-globulin (group-specific component) , is a protein that in humans is encoded by the GC gene. Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It is able to bind the various forms of vitamin D including ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) , the 25-hydroxylated forms (calcifediol) , and the active hormonal product, 1, 25-dihydroxyvitamin D (calcitriol) . The major proportion of vitamin D in blood is bound to this protein. It transports vitamin D metabolites between skin, liver and kidney, and then on to the various target tissues. As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells.