AffiAB® Anti-VDAC1 Antibody
Voltage-dependent anion-selective channel (VDAC1) (also referred to as porin, isoform 1) is a small protein, originally discovered in the outer membrane of mitochondria where it constitutes the major pore-forming protein. The porin protein VDAC1 allows to the outer-most membrane of the mitochondrion free permeability to low molecular-weight solutes. VDAC1 has been shown to co-immunoprecipitate with the anti-apoptotic protein Bcl-2 and suggested to be involved in forming the mitochondrial pore which releases cytochrome c during apoptosis.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P21796 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Zebrafish
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human VDAC1 aa 188-231.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Huntington's disease, 衰老, Calcium signaling pathway, Alzheimer disease, Parkinson’s disease, Amyotrophic lateral sclerosis, cGMP-PKG signaling pathway
Recommended dilutions
WB: 1:500; IHC-P: 1:200; IF-Cell: 1:200
Molecular Weight
31 kDa
Subcellular location
Mitochondrial membrane, cell membrane
Positive control
A431, human brain, Hela, Raji, HepG2, SW480