AffiAB® Anti-VASP Antibody [SY02-16]

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CAT# AFG-HB-4061
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-VASP Antibody [SY02-16]

The Wiskott-Aldrich syndrome (WAS) is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity, and a propensity for lymphoproliferative diseases. The syndrome is the result of a mutation in the gene encoding a proline-rich protein termed WASP. WASP has been identified as a downstream effector of Cdc42 and has been implicated in Actin polymer-ization and cytoskeletal organization. A distantly related protein, VASP (vaso-dilator-stimulated phosphoprotein) , is involved in the maintenance of cytoarchitecture by interacting with Actin-like filaments. VASP shares a limited degree of homology with the amino-terminus of WASP, which is frequently mutated in WAS patients. An established substrate of cAMP and cGMP de-pendent kinases, VASP is phosphorylated on a regulatory Serine residue 157 and localizes to focal adhesions, microfilaments and highly active regions of the plasma membrane. VASP is highly expressed in human platelets and, like WASP, may play a role in cytoskeletal organization.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P50552 Human

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

SY02-16

KO/KD

N/A

Species reactivity

Human

Tested applications

WB, IP

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human VASP aa 51-100 / 380.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

cGMP-PKG signaling pathway

Recommended dilutions

WB: 1:1, 000-1:2, 000

Molecular Weight

46 kDa

Subcellular location

Cytoplasm, Cell junction, Cell projection.

Positive control

HT29, MCF-7, Hela.