![AffiAB® Anti-USP24 Antibody [JE56-50]](/web/image/product.product/89254/image_1024/%5BAFG-HB-4040%5D%20AffiAB%C2%AE%20Anti-USP24%20Antibody%20%5BJE56-50%5D%20?unique=b83e256)
AffiAB® Anti-USP24 Antibody [JE56-50]
Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes .
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q9UPU5 Human; SwissProt: B1AY13 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JE56-50
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within C-terminal Human USP24.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000; IF-Cell: 1:50-1:100; IHC-P: 1:50-1:200
Molecular Weight
Predicted band size:294 kDa.
Subcellular location
Cytosol, nucleoplasm, nucleus.
Positive control
NIH/3T3 cell lysates, HepG2, human liver carcinoma tissue, human fetal skeletal muscle tissue, mouse liver tissue, mouse small intestine tissue.