![AffiAB® Anti-USP21 Antibody [16E1]](/web/image/product.product/89252/image_1024/%5BAFG-HB-4038%5D%20AffiAB%C2%AE%20Anti-USP21%20Antibody%20%5B16E1%5D%20?unique=8544d55)
AffiAB® Anti-USP21 Antibody [16E1]
USP21 (Ubiquitin Specific Peptidase 21) is a Protein Coding gene. Diseases associated with USP21 include Neurodevelopmental Disorder With Spasticity And Poor Growth. Among its related pathways are TNF signaling (REACTOME) and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and cysteine-type peptidase activity. An important paralog of this gene is USP2. Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: Q9UK80 Human; SwissProt: Q9QZL6 Mouse; SwissProt: B2GUX4 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgG1
Clone
16E1
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human USP21 aa 303-453 / 565.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB:1:500-1:2, 000; IF-Cell:1:50-1:100; IHC-P:1:50-1:200; FC:1:50-1:100
Molecular Weight
Predicted band size: 63 kDa
Subcellular location
Nucleus, cytoplasm.
Positive control
SH-SY5Y cell lysates, K562 cell lysates, 293T, rat seminal vesicle tissue, human liver tissue, human kidney tissue, human small intestine tissue, mouse heart tissue, SH-SY5Y cells.