AffiAB® Anti-UFO Antibody [C4-A8]
Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. AXL receptor tyrosine kinase has been shown to interact with TENC1.Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: P30530 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgG1
Clone
C4-A8
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell
Predicted species reactivity
N/A
Immunogen
Recombinant protein with Human UFO aa 10-160 / 894.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein G affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500; IF-Cell: 1:200-1:500
Molecular Weight
Predicted band size: 98 kDa
Subcellular location
Cell membrane.
Positive control
Recombinant protein lysate, SW480, LOVO.