![AffiAB® Anti-TXNIP Antibody [JM60-35]](/web/image/product.product/89190/image_1024/%5BAFG-HB-3974%5D%20AffiAB%C2%AE%20Anti-TXNIP%20Antibody%20%5BJM60-35%5D%20?unique=a48b62f)
AffiAB® Anti-TXNIP Antibody [JM60-35]
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q9H3M7 Human; SwissProt: Q8BG60 Mouse; SwissProt: Q5M7W1 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM60-35
KO/KD
Knockout validated
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human TXNIP aa 50-99 / 391.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:5, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:400; FC: 1:50-1:100
Molecular Weight
Predicted band size: 44 kDa
Subcellular location
Cytoplasm.
Positive control
PC-12 cell lysate, human skeletal muscle tissue lysate, NIH/3T3 cell lysate, Hela cell lysate, Hela, NIH/3T3, SH-SY5Y, human kidney tissue, human stomach tissue, mouse kidney tissue, mouse esophagus tissue, mouse stomach tissue.