![AffiAB® Anti-TWEAKR Antibody [SN20-07]](/web/image/product.product/89189/image_1024/%5BAFG-HB-3973%5D%20AffiAB%C2%AE%20Anti-TWEAKR%20Antibody%20%5BSN20-07%5D%20?unique=a48b62f)
AffiAB® Anti-TWEAKR Antibody [SN20-07]
Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q9NP84 Human; SwissProt: Q9CR75 Mouse; Entrez Gene: 302965 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
SN20-07
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, IP
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human TWEAKR aa 80-129 / 129.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Immunology & Inflammation
Recommended dilutions
WB: 1:500-1:1, 000
; IHC-P: 1:50-1:200
Molecular Weight
14 kDa
Subcellular location
Membrane.
Positive control
NIH/3T3 cell lysates , C2C12 cell lysates, mouse uterus tissue.