AffiAB® Anti-TTF1 Antibody [JE61-73]
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P43699 Human; SwissProt: P50220 Mouse; SwissProt: P23441 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JE61-73
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human TTF1 aa 272-371/371.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
IHC-P: 1:1000-1:5000
Molecular Weight
39 kDa
Subcellular location
Nucleus.
Positive control
Human lung carcinoma tissue, human thyroid carcinoma tissue, human thyroid tissue, mouse lung tissue, rat lung tissue.