![AffiAB® Anti-TNPO3 Antibody [JG38-77]](/web/image/product.product/89119/image_1024/%5BAFG-HB-3898%5D%20AffiAB%C2%AE%20Anti-TNPO3%20Antibody%20%5BJG38-77%5D%20?unique=a48b62f)
AffiAB® Anti-TNPO3 Antibody [JG38-77]
The Importin complex consists of Importin-α and Importin-β proteins which assist in transport of arginine- or serine-rich (SR) proteins across the nucleus. Importin-12, also known as Transportin-3 or Transportin-SR, is a member of the Importin-β family and functions as a nuclear transport receptor for serine/arginine-rich proteins. Through recognition of phosphorylated RS domains, Importin-12 mediates the nuclear import of several SR proteins, such as splicing factors SFRS1 and SFRS2. By regulating the nucleocytoplasmic transport of these and other SR mRNA splicing factors, Importin-12 controls their access to mRNA and, therefore, acts a transcriptional regulator.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q9Y5L0 Human; SwissProt: Q6P2B1 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JG38-77
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human TNPO3 aa 830-923 / 923.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IHC-P: 1:50-1:200
Molecular Weight
104 kDa
Subcellular location
Nucleus. Cytoplasm.
Positive control
K562 cell lysate, HL-60 cell lysate, mouse pancreas tissue lysate, A549, SH-SY5Y, SiHa, human liver carcinoma tissue, human small intestine tissue, mouse lung tissue, mouse kidney tissue.