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AffiAB® Anti-TMEM16A Antibody [PO00-27]
Anoctamin-1 (ANO1) also known as Transmembrane member 16A (TMEM16A) is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel and a bicarbonate channel. additionally Anoctamin-1 is apical iodide channel. It is expressed in smooth muscle, epithelial cells, vomeronasal neurons, olfactory sustentacular cells, and is highly expressed in interstitial cells of Cajal (ICC) throughout the gastrointestinal tract. ANO1 is a transmembrane protein that functions as a calcium-activated chloride channel. Ca2+, Sr2+, and Ba2+ activate the channel.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q5XXA6 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
PO00-27
KO/KD
N/A
Species reactivity
Human
Tested applications
IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human TMEM16A aa 400-500.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
PBS (pH7.4) , 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
IHC-P: 1:1, 000-1:1, 500
Molecular Weight
Predicted band size: 114 kDa
Subcellular location
Cytoplasm, Cell membrane.
Positive control
Human gastrointestinal stromal tumor tissue, human gallbladder tissue, human breast tissue.