![AffiAB® Anti-TDP43 Antibody [JM51-10]](/web/image/product.product/89027/image_1024/%5BAFG-HB-3799%5D%20AffiAB%C2%AE%20Anti-TDP43%20Antibody%20%5BJM51-10%5D%20?unique=a48b62f)
AffiAB® Anti-TDP43 Antibody [JM51-10]
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q13148 Human; SwissProt: Q921F2 Mouse; Unigene:2633 Rat; Entrez Gene:325052 Zebrafish
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM51-10
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IP, IF-Cell, IF-Tissue, IHC-P, FC
Predicted species reactivity
Rat, Zebrafish
Immunogen
Synthetic peptide within Human TDP43 aa 354-390 / 414; (2) aa 253-290 / 414.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Neuroscience, Amyotrophic lateral sclerosis
Recommended dilutions
WB: 1:500-1:5, 000; IF-Cell: 1:100-1:500; IF-Tissue: 1:100-1:500; IHC-P: 1:50-1:200; FC: 1:50-1:100; IP: Use at an assay dependent concentration.
Molecular Weight
Predicted band size: 45 kDa
Subcellular location
Cytoplasm, Mitochondrion, Nucleus.
Positive control
K562 cell lysate, Hela cell lysate, 293T, Hela, SH-SY5Y, human spleen tissue, human pancreas tissue, mouse placenta tissue.