AffiAB® Anti-SUZ12 Antibody
Polycomb protein SUZ12 is a nuclear protein belonging to the VEFS (VRN2-EMF2-FIS2-SUZ12) family. It is overexpressed in breast and colon cancer, expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q15022 Human; SwissProt: Q80U70 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human SUZ12 aa 481-520 / 739.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:2, 000-1:5, 000
Molecular Weight
Predicted band size: 83kDa
Subcellular location
Nucleus
Positive control
MCF-7, Hela, SW480, 293T, N2A F9