AffiAB® Anti-STAT6 Antibody
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L) , which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) , expression of cell surface markers, and class switch of immunoglobulins.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P42226 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
Knockdown validated
Species reactivity
Human
Tested applications
WB, IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within STAT6 aa 814-847/847.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Immunology & Inflammation, JAK-STAT signaling pathway
Recommended dilutions
WB: 1:1, 000; IF-Cell: 1:200; IHC-P: 1:200; FC: 1:100-1:200
Molecular Weight
Predicted band size: 94 kDa
Subcellular location
Cytoplasm, nucleus.
Positive control
Jurkat cell lysate, Raji cell lysate, Daudi cell lysate, Hela cell lysate, Ags cell lysate, human tosnsil tissue, human kidney tissue.