AffiAB® Anti-Spry2 Antibody

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CAT# AFG-HB-3671
Size: 100 μL

433.50 433.5 USD 433.50

433.50

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AffiAB® Anti-Spry2 Antibody

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Antibody type

Rabbit polyclonal Antibody

Uniprot ID

SwissProt: O43597 Human; Entrez Gene: 306141 Rat

Recombinant

NO

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

N/A

KO/KD

N/A

Species reactivity

Human, Rat

Tested applications

WB, IHC-P

Predicted species reactivity

N/A

Immunogen

Recombinant protein within human Spry2 aa 1-180.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

PBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Immunogen affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:500 ; IHC-P: 1:200

Molecular Weight

Predicted band size: 35 kDa

Subcellular location

Ruffle membrane, cytoskeleton.

Positive control

Rat liver tissue lysates, human liver tissue.