![AffiAB® Anti-SOCS2 Antibody [JG36-86]](/web/image/product.product/88874/image_1024/%5BAFG-HB-3638%5D%20AffiAB%C2%AE%20Anti-SOCS2%20Antibody%20%5BJG36-86%5D%20?unique=a48b62f)
AffiAB® Anti-SOCS2 Antibody [JG36-86]
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: O14508 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JG36-86
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IF-Tissue, IP, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human SOCS2 aa 1-198 / 198.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Type II diabetes mellitus, Immunology & Inflammation
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IP: 1:10-1:50; IHC-P: 1:1, 000
Molecular Weight
Predicted band size: 22 kDa
Subcellular location
Cytosol.
Positive control
Human placenta lysate, SH-SY-5Y cell lysate, K562 cell lysates, rat epididymis tissue, LOVO, PC-3M, SH-SY-5Y.