![AffiAB® Anti-SMC1A Antibody [SN20-27]](/web/image/product.product/88854/image_1024/%5BAFG-HB-3618%5D%20AffiAB%C2%AE%20Anti-SMC1A%20Antibody%20%5BSN20-27%5D%20?unique=a48b62f)
AffiAB® Anti-SMC1A Antibody [SN20-27]
Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. SMC1A is a subunit of the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of SMC1A, SMC3, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.SMC1A is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation from bacteria to humans.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q14683 Human; SwissProt: Q8NDV3 Human; SwissProt: Q920F6 Mouse; SwissProt: Q9CU62 Mouse; SwissProt: Q9Z1M9 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
SN20-27
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P
Predicted species reactivity
Rat
Immunogen
Synthetic peptide within Human SMC1A aa 1, 184-1, 233 / 1, 233.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:100-1:500; IF-Tissue: 1:100-1:500; IHC-P: 1:100-1:400
Molecular Weight
143 kDa
Subcellular location
Nucleus, Chromosome.
Positive control
Hela cell lysate, 293T cell lysate, Hela, A431, SW480, human breast carcinoma tissue, human lymph nodes tissue, mouse colon tissue, rat bladder tissue, rat large intestine tissue.