AffiAB® Anti-Smad2 Antibody

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CAT# AFG-HB-3606
Size: 100 μL

433.50 433.5 USD 433.50

433.50

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AffiAB® Anti-Smad2 Antibody

Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad) , have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad proteins.

Antibody type

Rabbit polyclonal Antibody

Uniprot ID

SwissProt: Q15796 Human

Recombinant

NO

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

N/A

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Cell, IHC-P

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within N-terminal human Smad2.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Immunogen affinity purified.

Signal pathway

衰老

Recommended dilutions

IF-Cell: 1:50-1:100; IHC-P:1:50-1:200

Molecular Weight

N/A

Subcellular location

Cytoplasm, Nucleus

Positive control

SW480, SK-BR-3, HepG2, mouse placenta tissue, human liver cancer tissue, mouse heart tissue, mouse skeletal muscle tissue