AffiAB® Anti-SLC22A2 Antibody

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine) , serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4- [4- (dimethylamino) -styryl] -N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN) , tetraethylammonium (TEA) , 1-methyl-4-phenylpyridinium (MPP) , cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.