AffiAB® Anti-SLC22A2 Antibody
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine) , serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4- [4- (dimethylamino) -styryl] -N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN) , tetraethylammonium (TEA) , 1-methyl-4-phenylpyridinium (MPP) , cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: O15244 Human; SwissProt: O70577 Mouse; SwissProt: Q9R0W2 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human SLC22A2 aa 44-150 / 555 (Extracellular) .
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB:1:500-1:1, 000
Molecular Weight
63/54/27 kDa
Subcellular location
Membrane.
Positive control
HepG2 cell lysate, 293T cell lysate, rat brain tissue lysate, mouse kidney tissue lysate, mouse brain tissue lysate.