![AffiAB® Anti-SHP2 Antibody [SN72-02]](/web/image/product.product/88813/image_1024/%5BAFG-HB-3574%5D%20AffiAB%C2%AE%20Anti-SHP2%20Antibody%20%5BSN72-02%5D%20?unique=a48b62f)
AffiAB® Anti-SHP2 Antibody [SN72-02]
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus .Positively regulates MAPK signal transduction pathway.Dephosphorylates GAB1, ARHGAP35 and EGFR.Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity.Dephosphorylates CDC73.Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q06124 Human; SwissProt: P35235 Mouse; SwissProt: P41499 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
SN72-02
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IP
Predicted species reactivity
Mouse, Rat
Immunogen
Synthetic peptide within N-terminal human SHP2.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
RAS signaling pathway, Immunology & Inflammation, JAK-STAT signaling pathway
Recommended dilutions
WB: 1:1, 000-1:5, 000
; IP: Use at an assay dependent concentration.
Molecular Weight
Predicted band size: 68 kDa
Subcellular location
Cytoplasm, Nucleus.
Positive control
Jurkat cell lysate, Hela cell lysate.