![AffiAB® Anti-SCAI Antibody [7-A4]](/web/image/product.product/88759/image_1024/%5BAFG-HB-3519%5D%20AffiAB%C2%AE%20Anti-SCAI%20Antibody%20%5B7-A4%5D%20?unique=315d7a9)
AffiAB® Anti-SCAI Antibody [7-A4]
Protein SCAI, also known as Suppressor of cancer cell invasion protein, and encoded by the gene name SCAI, is a tumor suppressor that suppresses MKL1-induced SRF transcriptional activity. It is a regulator of cell migration and appears to be involved in the RhoA (ras homolog gene family, member A) -Dia1 (diaphanous homolog 1) signal transduction pathway. SCAI localizes in the nucleus, where it binds and inhibits the myocardin-related transcription factor MAL by forming a ternary complex with serum response factor (SRF) .
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: Q8N9R8 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgM
Clone
7-A4
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human SCAI aa 1-606 / 606.
Storage
Store at -20°C. Stable for 12 months from date of receipt.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein L affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:1, 000-1:2, 000; IF-Cell: 1:50-1:200; IHC-P: 1:50-1:400
Molecular Weight
Predicted band size: 70 kDa
Subcellular location
Membrane. Nucleus. Cytoplasm.
Positive control
Recombinant protein, SHG-44, SH-SY-5Y, PC-12, human tonsil tissue, human lung tissue, human liver tissue, human brain tissue, human heart tissue, human pancreas tissue, human colon tissue