![AffiAB® Anti-SARA Antibody [JE63-65]](/web/image/product.product/88743/image_1024/%5BAFG-HB-3503%5D%20AffiAB%C2%AE%20Anti-SARA%20Antibody%20%5BJE63-65%5D%20?unique=b83e256)
AffiAB® Anti-SARA Antibody [JE63-65]
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: O95405 Human; Entrez Gene: 313477 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JE63-65
KO/KD
N/A
Species reactivity
Human, Rat
Tested applications
WB
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human SARA aa 1-50/1, 425.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1, 000
Molecular Weight
Predicted band size: 156 kDa
Subcellular location
Early endosome membrane, Cytoplasm.
Positive control
HUVEC cell lysate, rat brain tissue lysate, Hela cell lysate, SiHa cell lysate, PC-3 cell lysate.