![AffiAB® Anti-RRM2 Antibody [JM93-43]](/web/image/product.product/88701/image_1024/%5BAFG-HB-3458%5D%20AffiAB%C2%AE%20Anti-RRM2%20Antibody%20%5BJM93-43%5D%20?unique=a48b62f)
AffiAB® Anti-RRM2 Antibody [JM93-43]
Belongs to the ribonucleoside diphosphate reductase small chain family. Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.it have two regulatory sites: the specificity site, which controls substrate specificity, and the activity site which regulates overall catalytic activity. A substrate-binding catalytic site, located on M1, is formed only in the presence of the second subunit M2.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P31350 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM93-43
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IP, IF-Cell, IF-Tissue
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human RRM2 aa 1-147 / 389.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
p53 signaling pathway
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:20-1:50; IF-Tissue: 1:20-1:50; IP: 1:10-1:50
Molecular Weight
Predicted band size: 45 kDa
Subcellular location
Cytoplasm, Nucleus.
Positive control
HepG2 cell lysate, Hela cell lysate.