AffiAB® Anti-RRM1 Antibody [JB09-43]

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CAT# AFG-HB-3457
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-RRM1 Antibody [JB09-43]

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1) , with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P23921 Human; SwissProt: P07742 Mouse

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

JB09-43

KO/KD

N/A

Species reactivity

Human, Mouse

Tested applications

WB, IHC-P, FC, IP

Predicted species reactivity

N/A

Immunogen

Recombinant protein within Human RRM1 aa 651-792 / 792.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:500-1:2, 000 ; IHC-P: 1:50-1:100 ; FC: 1:50-1:100 ; IP:1:10-1:50

Molecular Weight

Predicted band size: 90 kDa

Subcellular location

Cytoplasm.

Positive control

Mouse thymus tissue lysate, A431 cell lysate, human colon tissue, A431.