AffiAB® Anti-RON Antibody

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CAT# AFG-HB-3437
Size: 100 μL

433.50 433.5 USD 433.50

433.50

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AffiAB® Anti-RON Antibody

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Antibody type

Rabbit polyclonal Antibody

Uniprot ID

SwissProt: Q04912 Human

Recombinant

NO

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

N/A

KO/KD

N/A

Species reactivity

Human

Tested applications

IF-Cell, IHC-P

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within C-terminal human RON.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Immunogen affinity purified.

Signal pathway

Immunology & Inflammation

Recommended dilutions

IF-Cell: 1:50-1:200; IHC-P: 1:50-1:200

Molecular Weight

Predicted band size: 152 kDa

Subcellular location

Membrane.

Positive control

A549, Ags, SW480, human breast tissue, human breast cancer tissue, human stomach cancer tissue.