![AffiAB® Anti-RANTES Antibody [JM03-45]](/web/image/product.product/88617/image_1024/%5BAFG-HB-3366%5D%20AffiAB%C2%AE%20Anti-RANTES%20Antibody%20%5BJM03-45%5D%20?unique=a48b62f)
AffiAB® Anti-RANTES Antibody [JM03-45]
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) . The processed form RANTES (3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES (4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES (1-68) and RANTES (3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P13501 Human; SwissProt: P30882 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM03-45
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IHC-P, IF-Cell, IF-Tissue
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human RANTES aa 1-100.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200
Molecular Weight
Predicted band size: 10 kDa
Subcellular location
Secreted.
Positive control
Mouse thymus lysates, Hela, HUVEC, human tonsil tissue, human placenta tissue.