AffiAB® Anti-RANTES Antibody [JM03-45]

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CAT# AFG-HB-3366
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-RANTES Antibody [JM03-45]

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) . The processed form RANTES (3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES (4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES (1-68) and RANTES (3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P13501 Human; SwissProt: P30882 Mouse

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

JM03-45

KO/KD

N/A

Species reactivity

Human, Mouse

Tested applications

WB, IHC-P, IF-Cell, IF-Tissue

Predicted species reactivity

N/A

Immunogen

Recombinant protein within human RANTES aa 1-100.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:500-1:1, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200

Molecular Weight

Predicted band size: 10 kDa

Subcellular location

Secreted.

Positive control

Mouse thymus lysates, Hela, HUVEC, human tonsil tissue, human placenta tissue.