AffiAB® Anti-Rab4A Antibody [SR27-08]

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CAT# AFG-HB-3335
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-Rab4A Antibody [SR27-08]

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab superfamilies, exhibits 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possiblity that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab family have been identified, each of which is found at a particular stage of a membrane transport pathway.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P20338 Human; SwissProt: P56371 Mouse; SwissProt: P05714 Rat

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

SR27-08

KO/KD

N/A

Species reactivity

Human, Rat, Monkey

Tested applications

WB, IF-Cell, IF-Tissue, IP

Predicted species reactivity

Mouse

Immunogen

Synthetic peptide within Human Rab4A aa 169-218 / 218.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

Neuroscience

Recommended dilutions

WB: 1:500; IF-Cell: 1:50; IF-Tissue: 1:50; IP: Use at an assay dependent concentration.

Molecular Weight

Predicted band size: 24 kDa

Subcellular location

Cytoplasm, Membrane

Positive control

MCF-7 cell lysate, 293T cell lysate, COS-1 cell lysate, PC-12.