![AffiAB® Anti-PTPRB Antibody [2-A2]](/web/image/product.product/77769/image_1024/%5BAFG-HB-3316%5D%20AffiAB%C2%AE%20Anti-PTPRB%20Antibody%20%5B2-A2%5D%20?unique=315d7a9)
AffiAB® Anti-PTPRB Antibody [2-A2]
DNA (cytosine-5) -methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L Receptor-type tyrosine-protein phosphatase beta is an enzyme that in humans is encoded by the PTPRB gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRB plays an important role in blood vessel remodeling and angiogenesis. It is not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. PTPRB can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. It regulates angiopoietin-TIE2 signaling in endothelial cells.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: P23467 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgG2a
Clone
2-A2
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
IF-Cell
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human PTPRB aa 1, 018-1, 161 / 1, 997.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein G affinity purified.
Signal pathway
N/A
Recommended dilutions
IF-Cell: 1:1, 000
Molecular Weight
224kDa
Subcellular location
Membrane
Positive control
F9