![AffiAB® Anti-PTBP1 Antibody [JU41-20]](/web/image/product.product/77763/image_1024/%5BAFG-HB-3307%5D%20AffiAB%C2%AE%20Anti-PTBP1%20Antibody%20%5BJU41-20%5D%20?unique=a48b62f)
AffiAB® Anti-PTBP1 Antibody [JU41-20]
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P26599 Human; SwissProt: P17225 Mouse; SwissProt: Q00438 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JU41-20
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human PTBP1 aa 20-69 / 531.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-2, 000
; IHC-P: 1:50-1:200
Molecular Weight
57 kDa
Subcellular location
Nucleus.
Positive control
K562 cell lysate, Jurkat cell lysate, human tonsil tissue, human skin tissue, human kidney tissue, mouse colon tissue, human lymph nodes tissue, mouse large intestine tissue.