AffiAB® Anti-PPP1CA Antibody
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1) . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P62136 Human; SwissProt: P62137 Mouse; SwissProt: P62138 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human PPP1CA aa 291-330.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
衰老, cAMP signaling pathway, Neuroscience, cGMP-PKG signaling pathway
Recommended dilutions
WB: 1:500-1:2, 000
; IHC-P: 1:50-1:200
Molecular Weight
38 kDa
Subcellular location
Nucleus, nucleoplasm, nucleolus, cytoplasm.
Positive control
MCF-7 cell lysate, A549 cell lysate, K562 cell lysate, Hela cell lysate, rat brain tissue lysate, mouse brain tissue lysate, rat large intestine tissue, mouse kidney tissue.