![AffiAB® Anti-Podoplanin Antibody [JM31-21]](/web/image/product.product/77650/image_1024/%5BAFG-HB-3189%5D%20AffiAB%C2%AE%20Anti-Podoplanin%20Antibody%20%5BJM31-21%5D%20?unique=a48b62f)
AffiAB® Anti-Podoplanin Antibody [JM31-21]
Puromycin aminonucleoside nephrosis (PAN) is a rat model for human minimal change nephropathy. During PAN, severe proteinuria is induced that is paralleled by a reduced expression of a rat podocyte protein, named podoplanin. Podoplanin, also known as glycoprotein 38 (gp38) is a type I membrane protein. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q86YL7 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM31-21
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human Podoplanin aa 35-75 / 162.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000
; IHC-P: 1:50-1:400
Molecular Weight
Predicted band size: 17 kDa
Subcellular location
Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane.
Positive control
Human lung tissue lysates, human lung tissue, human breast tissue.